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1. Company Snapshot

1.a. Company Description

Lyell Immunopharma, Inc., a T cell reprogramming company, engages in developing T cell therapies for patients with solid tumors.The company develops therapies using technology platforms, such as Gen-R, an ex vivo genetic reprogramming technology to overcome T cell exhaustion; and Epi-R, an ex vivo epigenetic reprogramming technology to generate population of T cells with durable stemness.Its pipeline includes LYL797, a T cell product candidate for the treatment of non-small cell lung cancer and triple negative breast cancers; LYL845, that targets multiple solid tumors; and NY-ESO-1 for synovial sarcoma and other solid tumor indications.


The company entered into research and development collaboration and license agreement with GlaxoSmithKline for NY-ESO-1 program.Lyell Immunopharma, Inc.was incorporated in 2018 and is headquartered in South San Francisco, California.

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1.b. Last Insights on LYEL

Negative drivers behind Lyell Immunopharma's recent stock performance include the heavy selling pressure, which led to a technically oversold stock. However, the company's recent participation in investor conferences and positive initial clinical data from the Phase 1-2 clinical trial of IMPT-314 for the treatment of B-cell lymphoma, presented at the 2024 ASH Annual Meeting, may have alleviated some concerns.

1.c. Company Highlights

2. Transcript Summary

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3. NewsRoom

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Lyell Immunopharma Reports Business Highlights and Financial Results for the Third Quarter 2025

Nov -12

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Lyell Immunopharma Acquires Exclusive Global Rights to a Next-Generation CAR T-Cell Product Candidate in Clinical Development for Metastatic Colorectal Cancer

Nov -10

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Lyell Announces Two Oral Presentations from the Phase 1/2 Clinical Trial of Ronde-Cel for the Treatment of Aggressive Large B-Cell Lymphoma at the 67th ASH Annual Meeting and Exposition

Nov -03

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Lyell Immunopharma Announces the Initiation of a Phase 3 Head-to-Head CAR T-Cell Therapy Clinical Trial in Aggressive Large B-Cell Lymphoma and Formation of Expert Steering Committee

Sep -03

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Lyell Immunopharma Announces Participation in September Investor Conferences

Sep -02

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Lyell Immunopharma Reports Business Highlights and Financial Results for the Second Quarter 2025

Aug -12

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Lyell Immunopharma Announces up to $100 Million Equity Private Placement

Jul -25

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Lyell: 'Hold' Rating Based On Phase 3 LYL314 LBCL Treatment Program Advancement

Jul -22

4. Business Breakdown

4.a. Revenues by Country

4.b. Revenues by Segment

5. Expected revenues mid-term growth (0.00%)

6. Segments

T-Cell Therapies

Expected Growth: 15.4%

Increasing adoption of personalized cancer treatments, advancements in T-cell therapy, and growing demand for targeted cancer therapies drive the growth of Lyell Immunopharma's T-Cell Therapies.

7. Detailed Products

eTIL

A personalized neoantigen-based immunotherapy for the treatment of solid tumors

Lymphoma Program

A cell-based immunotherapy for the treatment of lymphoma

Solid Tumor Program

A personalized neoantigen-based immunotherapy for the treatment of solid tumors

T Cell Receptor (TCR) Program

A T cell receptor-based immunotherapy for the treatment of various cancers

8. Lyell Immunopharma, Inc.'s Porter Forces

Forces Ranking

Threat Of Substitutes

The threat of substitutes for Lyell Immunopharma, Inc. is medium due to the presence of alternative treatments and therapies for cancer and autoimmune diseases.

Bargaining Power Of Customers

The bargaining power of customers for Lyell Immunopharma, Inc. is low due to the lack of negotiating power of individual patients and the high demand for innovative cancer and autoimmune disease treatments.

Bargaining Power Of Suppliers

The bargaining power of suppliers for Lyell Immunopharma, Inc. is medium due to the presence of multiple suppliers for raw materials and equipment, but the high demand for specialized components.

Threat Of New Entrants

The threat of new entrants for Lyell Immunopharma, Inc. is high due to the growing interest in immunotherapy and the increasing number of biotech startups and pharmaceutical companies entering the market.

Intensity Of Rivalry

The intensity of rivalry for Lyell Immunopharma, Inc. is high due to the presence of established pharmaceutical companies and biotech firms, as well as the increasing competition for market share and talent.

9. SWOT Analysis

10. Capital Structure

10.a. Balance Sheet

10.b. Weighted Average Cost of capital

Value
Debt Weight 8.80%
Debt Cost 3.95%
Equity Weight 91.20%
Equity Cost 1.19%
WACC 1.44%
Leverage 9.64%

11. Quality Control: Lyell Immunopharma, Inc. passed 3 out of 9 key points

12.a Historical Valuation

12.b Price/Earnings Ratio

12.c Margin Valuation

12.d Peers Valuation

Peers Group Analysis

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Ginkgo Bioworks

A-Score: 4.3/10

Value: 7.8

Growth: 3.3

Quality: 4.3

Yield: 0.0

Momentum: 9.5

Volatility: 1.0

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VBI Vaccines

A-Score: 3.9/10

Value: 9.8

Growth: 6.1

Quality: 2.4

Yield: 0.0

Momentum: 5.0

Volatility: 0.0

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Relay Therapeutics

A-Score: 3.6/10

Value: 6.8

Growth: 6.9

Quality: 3.8

Yield: 0.0

Momentum: 2.5

Volatility: 1.7

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MacroGenics

A-Score: 3.3/10

Value: 8.4

Growth: 6.0

Quality: 3.8

Yield: 0.0

Momentum: 0.5

Volatility: 1.0

1-Year Total Return ->

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Lyell Immunopharma

A-Score: 3.2/10

Value: 7.6

Growth: 1.0

Quality: 4.7

Yield: 0.0

Momentum: 5.5

Volatility: 0.7

1-Year Total Return ->

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Generation Bio

A-Score: 3.2/10

Value: 8.6

Growth: 5.4

Quality: 3.8

Yield: 0.0

Momentum: 0.5

Volatility: 0.7

1-Year Total Return ->

Peers Metrics

12.e Scoring Insights

12.f DCF BETA

Parameters

Short Term Growth

Short term Time

Long-Term Growth

WACC

Target Price

25.25$

Current Price

25.25$

Potential

0.00%

Expected Cash-Flows